General Meeting of the American Society of Microbiology
Today at 10:45am at the General Meeting of the American Society of Microbiology, please stop by Session 098, Poster 1069, as Garrett Reymann, MB(ASCP), Molecular Diagnostics Implementation Specialist with Dynacare Laboratories in Milwaukee, presents data about iCubate's blood stream infection diagnostic test ...
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American Society of Microbiology
Looking forward to seeing colleagues at the American Society of Microbiology. Please stop by Booth 115 to visit with members of the iCubate team and see the iCubate System. Also, follow us on Twitter (@icubating) or on LinkedIn - iCubate." ...
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iCubate begins clinical study of new bloodstream bacteria detector
iCubate Inc., a biotechnology company at the HudsonAlpha Institute for Biotechnology, has begun clinical studies of a product to detect the most common cause of bacterial bloodstream infections. The test would identify gram-positive bacteria such as staphylococcus, which are common bacterial blood contaminants. Earlier Beta testing at three laboratories verified the product's performance, the company said. "In order to provide the best treatment to patients, physicians need an accurate diagnosis," iCubate founder and chairman Dr. Jian Han said in a statement today. "iCubate will provide this using groundbreaking multiplex technology and an innovative platform." The company says its disposable test cassette ...
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iCubate receives Frost & Sullivan North American New Product Innovation Award
Huntsville, Ala. -iCubate, Incorporated, a privately held molecular diagnostic company, has won the Frost and Sullivan 2012 North American Product Innovation Award in PCR Technology. "We are honored to be recognized by Frost and Sullivan for this prestigious award," said Carter Wells, iCubate's chief executive officer. "iCubate will bring a comprehensive, personalized diagnostic tool to the market for health care providers who seek to provide personalized treatments for patients." The iCubate System is designed to provide accurate, rapid detection of multiple pathogens in a disposable cassette. Debuting as a research-only platform, iCubate is pursuing FDA clearance for its platform and ...
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PCR, qPCR and mPCR
No one can imagine biotech without PCR. There are many variations of the basic PCR technology, just visit the Wikipedia link, to find more than 20 different PCR based methods. qPCR or real time PCR, is one of the most popular technologies today. It is popular because it has several desired features. It is sensitive, quantitative, and it integrates amplification and detection. However, it is very difficult to develop a multiplex assay for qPCR. We have been focused on developing mPCR (multiplex PCR) technologies for the past 10 years. We first invented the patented tem-PCR technology (for target enriched multiplex ...
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PPI helps you design better PCR primers
PPI stands for polymerase preference index (patent pending). It is an algorithm we developed to help select the best performing PCR primers based on polymerase preference. Most of the primer design softwares evaluate the melting temperature (TM) as the most important parameter. But TM, at its best, could only tell us if a primer would bind to the template at certain temperature; it tells us nothing about if the primers will be used or preferred by the DNA polymerase. To evaluate polymerase preference, we analyzed high throughput sequencing data where random hexamers were used as primers to amplify genomic DNA ...
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iCubate 2.0, an open platform for assay developers
iCubate 2.0 is an idea we borrowed from the IT industry where the Web 2.0 business model has already transformed our lives. Here, the “2.0” means “user generated content and an online store”. So, iCubate 2.0 is an open platform that allow users to develop and market multiplex PCR (mPCR) assays. We call this kind of assay “iC”. An iC is a multiplex PCR assay designed with the PPI algorithm, powered by the arm-PCR technology, and performed on an iCubate platform. To help users developing powerful mPCR iCs, we have incorporated our assay design knowledge into an software, iC-Architect, and ...
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Why we care about the design of the instrument?
Walking into a clinical molecular diagnostic lab, you will see many boring, gray, ugly shaped machines. It seams nobody is willing to make that little extra effort to design a better looking instrument. The plastic shells are almost always an after thought, simply to cover up the guts. With iCubate, we paid attention to aesthetic value at the very beginning of the development process. We want the machine to look good, so that the operators will feel good, and in return, they will generate results that make patients feel better. So, these are our instrument: The system include a processor ...
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